Phenylthiourea enhances Cu cytotoxicity in cell cultures: Its mode of action.
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چکیده
منابع مشابه
Comparison of human corneal cell cultures in cytotoxicity testing.
The cytotoxic pattern of cosmetic or pharmaceutical compounds within different layers of the human cornea is of special interest with respect to ocular safety testing. The aim of this study was to evaluate the ability of a newly developed human corneal keratocyte (HCK) cell line as an in vitro model to predict toxicity towards keratocytes in the corneal stroma. The cytotoxic response of immorta...
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See related article by Eagle and Foley, Cancer Res 1958;18: 1017–25. From a contemporary perspective in 2016, it is difficult to realize that not very long ago, the prevailing primary screen for testing new anticancer drugs was the demonstration of their therapeutic activity in vivo in animal models. Such assays were performed in mice that had been previously transplanted with highly malignant ...
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Thymidylate synthase (TS) is a cell cycle regulated enzyme. It increases during proliferation and has a higher activity during the S-phase in order to provide the cell with sufficient dTTP to facilitate DNA synthesis. Hence inhibition of cyclin dependent kinases (CdK) may lead to a decrease of TS and enhance the inhibition of TS. A number of CdKs control progress of the cell cycle together with...
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The muscle-specific, basic helix-loop-helix transcription factor MyoD can induce cells from other mesenchymal lineages to express a skeletal muscle phenotype. Interestingly, MyoD is initially upregulated in myogenic cells incubated with bone morphogenetic proteins (BMPs), a treatment that induces osteogenic differentiation, suggesting that MyoD has a role in BMP-induced osteogenesis of myogenic...
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Jackie Stephen-Haynes is Consultant Nurse and Senior Lecturer in Tissue Viability for Worcestershire Primary Care Trusts and University of Worcester; Rosie Callaghan is Tissue Viability Specialist Nurse in nursing homes, Worcestershire PCT This article outlines the key actions of honey when used as a treatment for wounds and examines the evidence base for its efficacy and impact on clinical out...
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ژورنال
عنوان ژورنال: Cell Structure and Function
سال: 1984
ISSN: 0386-7196,1347-3700
DOI: 10.1247/csf.9.25